Neuropeptide substance P and the immune response
نویسندگان
چکیده
منابع مشابه
History of a Pioneering Neuropeptide: Substance P
1 Extraction, Biological Testing and Structural Elucidation . . . . . . . . . . . . 1 2 Masanori Otsuka and the Action of Substance P in the Spinal Cord . . . . . . 8 3 Radioimmunoassay and Immunohistochemistry of Substance P . . . . . . . . 8 4 Nicolas Jancs and Capsaicin . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 5 Peptide and Nonpeptide Transmitters in Primary Afferent Neuron...
متن کاملModulation of lymphatic muscle contractility by the neuropeptide substance P.
Substance P (SP) is a neuropeptide associated with sensory innervation of lymphoid tissue and a suspected modulator of lymphatic function in inflammation. Only a few studies have examined the effects of SP on lymphatic contraction, and it is not clear to what extent SP acts directly on the lymphatic muscle and/or endothelium or indirectly through changes in intraluminal filling pressure seconda...
متن کاملEffects of a Skin Neuropeptide (Substance P) on Cutaneous Microflora
BACKGROUND Skin is the largest human neuroendocrine organ and hosts the second most numerous microbial population but the interaction of skin neuropeptides with the microflora has never been investigated. We studied the effect of Substance P (SP), a peptide released by nerve endings in the skin on bacterial virulence. METHODOLOGY/PRINCIPAL FINDINGS Bacillus cereus, a member of the skin transi...
متن کاملThe neuropeptide substance P mediates adventitial mast cell activation and induces intraplaque hemorrhage in advanced atherosclerosis.
RATIONALE Although we and others have recently shown that mast cells play an important role in plaque progression and destabilization, the nature of the actual trigger for (peri)vascular mast cell activation during atherosclerosis is still unresolved. OBJECTIVE In this study, we confirm that perivascular mast cell content correlates with the number of nerve fibers in the adventitia of human c...
متن کاملThe Role of the Neuropeptide Substance P in the Pathogenesis of Parkinson’s Disease
Parkinson’s disease (PD) was first described by James Parkinson in 1815 as “shaking palsy syndrome”. Today, it is the second most common neurodegenerative disorder, with a lifetime risk of 1 in 45 of developing the debilitating disease and currently affecting 1% of the population over the age of 65 (G. Alves, et al., 2008). PD is characterized by a slow and progressive loss of the pigmented dop...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2016
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-016-2293-z